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November 2015

Volume 1  Issue 2

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Review Article

Epigenetic of Aerobic Exercise and the Aging Processes

Moran Sagiv*, David Ben Sira, Michael Sagiv, Ehud Goldhammer

Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death. Physical inactivity that typically occur in aging also decrease maximal oxygen uptake. Successful aging is a function of both genetic and environmental factors. The primary aging process, itself genetically associated, occurs both independently of life style and in the absence of disease. No matter what genes one has inherited, the body is continually undergoing complex biochemical reactions. Some of these reactions cause damage and, ultimately, aging in the body.

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Research Article

Physical and Psychosocial Outcomes of People with Dementia in Shared Housing Arrangements – A Cluster-Randomized Study on Long-Term Progression

Karin Wolf-Ostermann, Saskia Meyer, Andreas Worch, Johannes Gräske

Since the number of people with dementia (PwD) is rapidly increasing all over the world great efforts are made to improve care in general as well as to design and evaluate special care settings for PwD. The design of living environments has an impact on behavioural problems of PwD. But in general, there is no consensus on the supremacy of one special care setting in terms of beneficial aspects (e. g. challenging behaviour, quality of life …) for PwD.

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Case Report

Left Sided Aspiration Pneumonia

Ji Hye Lim, Gauri Gogna, Peter Stride

The usual presentation of aspiration pneumonia in the right lower lobe is predicated by the anatomy of the bronchial tree. The left main bronchus is 60° from the vertical plane, being displaced superiorly by the heart, while the right main bronchus is only 30° from the vertical; therefore aspiration is more common down the right side.

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Scientific Article

Klotho gene expression responses to long lasting aerobic training and aging

Moran Saghiv, Ehud Goldhammer, Michael Sagiv, David Ben-Sira

The primary aging process which is genetically associated occurs independently of life style and the presence of disease.Therefore, successful aging is a function of both genetic and environmental factors. Multiple age related structural and functional changes are involved in skeletal, cardiac and oxygen delivery ability during the human senescence. Aging results in a significant decline in aerobic capacity and in the expression of a gene located on chromosome 13: Klotho gene a suppressor of the aging phenomena, as well as the circulation of s-Klotho proteins.

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Research Article

Ageing-Associated Inflammation ( Inflammageing ) : Multiplex Cytokine Analysis In Healthy Japanese Individuals

Makoto Goto, Koichiro Hayata, Junji Chiba, Masaaki Matsuura, Sachiko Iwaki-Egawa,Yasuhiro Watanabe

Ageing is tightly associated with minor and life-long environmental insults, leading to a chronic and systemic inflammation, named “inflammageing”. We reported the healthy ageing-associated elevation of highly sensitive CRP ( hsCRP ) in Japanese individuals aged between 1 and 100 years and the patients with Werner syndrome in the previous paper. To further study the association of hsCRP and 26 cytokines/chemokines, a multiple cytokine array system was used in the same serum samples as were examined for hsCRP from healthy Japanese adults.

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Review Article

Managing Geriatric Patients with Depression, Cognitive Change, and Culture/Sexuality Differences: Evidence-Based Assessment, Treatment, Models of Care and Telehealth Innovations

Donald M. Hilty*, Andreea L. Seritan, Tammy Duong, Peter J. Ureste , Laura A. Mosqueda

The proportion of older adults is growing faster than any other age group as a result of longer life expectancy and declining fertility rates. Older adults can be particularly atrisk given other health problems, reduced access to appropriate care, and poorer self-assessment of their health than urban counterparts. Up to 39% of older patients suffer from depression or depressive symptoms. Dementia was estimated to affect 44 million people worldwide in 2013 and this number is expected to reach 76 million in 2030 and 135 by 2050.

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Research Article

Change in Resident Weight Status Post Admission to Long-Term Care Facilities: A Population-Based Study

Helen E. Battisti*, Lee Harrison, Alan M. Levine, Geraldine T. Dawson

Research has demonstrated that newly admitted residents to long-term care facilities throughout America are entering at a higher weight. But once admitted, is there a “Freshman 15” weight gain that further compromises the health and well-being of those residents who are already overweight or obese? Currently there is limited research examining the change in weight after admission to long-term care facilities in the United States. This research provides a foundation study for future investigation.

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